Multidimensional Personality Changes Following Psilocybin-Assisted Therapy in Patients With Alcohol Use Disorder: Results From a Double-Blind, Placebo-Controlled Clinical Trial
Noam Goldway, Snehal Bhatt, Stephen Ross, Broc A. Pagni, Richard J. Zeifman, Sarah E. Mennenga, Brennan M. Carrithers, Kelley C. O’donnell, Michael P. Bogenschutz
American Journal of Psychiatry 2025 DOI: 10.1176/appi.ajp.20230887 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Placebo-controlled Double-blind Peer reviewed |
|---|---|
| Population | People with alcohol use disorder |
| Intervention | Psilocybin-assisted therapy |
| Topics | Addiction Psilocybin |
| Keywords | Alcohol dependence Placebo Clinical psychology Personality disorders Randomized controlled trial Trait Psychotherapist |
| Citations | 23 |
| Key findings | Psilocybin-assisted therapy produced durable shifts in personality, suggesting normalization of abnormal personality trait expression in alcohol use disorder. |
Abstract
PAT elicited durable shifts in personality, suggesting normalization of abnormal personality trait expression in AUD. Further study is needed to clarify whether PAT exerts its beneficial effects by reducing impulsiveness or whether impulsive individuals inherently respond better to PAT.
Comparable studies
Other randomized controlled trials on psilocybin for addiction, most cited first.