Multidimensional Personality Changes Following Psilocybin-Assisted Therapy in Patients With Alcohol Use Disorder: Results From a Double-Blind, Placebo-Controlled Clinical Trial
Noam Goldway, Snehal Bhatt, Stephen Ross, Broc A. Pagni, Richard J. Zeifman, Sarah E. Mennenga, Brennan M. Carrithers, Kelley C. O’donnell, Michael P. Bogenschutz
American Journal of Psychiatry 2025 DOI: 10.1176/appi.ajp.20230887 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Placebo-controlled Double-blind Peer reviewed |
|---|---|
| Population | People with alcohol use disorder |
| Intervention | Psilocybin-assisted therapy |
| Topics | Addiction Psilocybin |
| Keywords | Alcohol dependence Placebo Clinical psychology Personality disorders Randomized controlled trial Trait Psychotherapist |
| Citations | 23 |
| Key findings | Psilocybin-assisted therapy produced durable shifts in personality, suggesting normalization of abnormal personality trait expression in alcohol use disorder. |
Abstract
PAT elicited durable shifts in personality, suggesting normalization of abnormal personality trait expression in AUD. Further study is needed to clarify whether PAT exerts its beneficial effects by reducing impulsiveness or whether impulsive individuals inherently respond better to PAT.
Comparable studies
Other randomized controlled trials on psilocybin for addiction, most cited first.
Citations in the library
Cited by 20
- The Emergence of Psilocybin in Psychiatry and Neuroscience Pharmaceuticals April 9, 2025
- Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach. Frontiers in Psychiatry 2025
- Psychedelics for Alcohol Use Disorder: A Narrative Review with Candidate Mechanisms of Action. CNS Drugs July 10, 2025
- Exploring serotonergic psychedelics as a treatment for personality disorders. Neuropharmacology July 1, 2025
- Psychedelic therapeutics in psychiatric conditions Neuropsychopharmacology January 16, 2026
and 15 more in the library
Cites 22
- Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness Journal of Psychopharmacology September 28, 2011
- Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder JAMA Psychiatry August 24, 2022
- Psilocybin-Occasioned Mystical Experiences in the Treatment of Tobacco Addiction Current Drug Abuse Reviews January 9, 2015
- Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies Acta Psychiatrica Scandinavica October 30, 2020
- Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial. EClinicalMedicine February 1, 2023
and 17 more in the library