Mindful Self-Compassion to Reduce Pain Interference Among Adults with Osteogenesis Imperfecta.
Amena Sediqi, Roya Al-Khalili, Saunya Dover, Corien Peeters, Adam Khalif, V Reid Sutton, Frank Rauch, Brendan Lee, Eric A Storch, Marie-Eve Robinson
Journal of clinical psychology in medical settings August 14, 2025 DOI: 10.1007/s10880-025-10092-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Pilot intervention study Pilot study Peer reviewed |
|---|---|
| Sample size | 7 |
| Population | Adults with osteogenesis imperfecta and co-occurring chronic pain |
| Duration | 8-week intervention |
| Measures | Intervention Acceptability Framework, PROMIS pain interference questionnaire, ActiGraph GT9X Link watch |
| Topics | Meditation |
| Keywords | Humans Osteogenesis imperfecta Feasibility studies Pilot projects Empathy Adult Middle aged Female Pain management Chronic pain Surveys and questionnaires Chronic disease Positive psychology Mindful self-compassion |
| Key points | The Mindful Self-Compassion program was feasible, with high attendance and questionnaire completion, and 86% (6/7) of participants found it acceptable. Although the pilot was not powered to show efficacy, pain interference on the PROMIS questionnaire decreased from a mean of 55.9 at baseline to 50.0 at 8 weeks. |
Abstract
Between 60 and 80% of adults with osteogenesis imperfecta (OI) experience chronic pain and associated interference. Currently available pain therapies often provide marginal efficacy. Mindful self-compassion (MSC) has emerged as a promising intervention for coping with chronic pain. We conducted a single-center 8-week pilot intervention study to assess the feasibility and acceptability of a MSC program among adults with OI and co-occurring chronic pain. Individuals attended the validated MSC course consisting of 8 weekly virtual 2-h sessions. Participants completed a battery of validated questionnaires assessing pain, various aspects of well-being, and physical function at baseline and post-intervention. Participants wore the ActiGraph GT9X Link watch to measure sleep duration and sleep efficiency. Seven adults with OI and co-occurring pain participated in the MSC program. The program was feasible, as indicated by high attendance and high questionnaire completion rates. Participants reported a mean ± standard deviation (SD) of 3.5 out of 5 ± 0.4 on the Intervention Acceptability Framework. 86% (6/7) of participants found the MSC program to be acceptable. While our pilot study was not powered to show efficacy, we observed a decrease in pain interference on the PROMIS pain interference questionnaire (mean 55.9 ± 5.5 at baseline vs. 50.0 ± 7.3 at 8 weeks). Implementation of the MSC program is feasible as a potential therapeutic option to address chronic pain in OI.
Citations in the library
Cites 3
- A Mindfulness Program Adapted for Adolescents With Chronic Pain Clinical Journal of Pain November 1, 2017
- A mindful self-compassion videoconference intervention for nationally recruited posttreatment young adult cancer survivors: feasibility, acceptability, and psychosocial outcomes. Supportive Care in Cancer January 19, 2017
- A pilot study and randomized controlled trial of the mindful self-compassion program. Journal of Clinical Psychology October 15, 2012