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Novel Phenethylamines as 5‑HT2A Agonists for Treating Depression, Drug Addiction, Alcoholism, PTSD, and Neuropathic Pain.

Ram W. Sabnis

ACS Medicinal Chemistry Letters July 2, 2025 DOI: 10.1021/acsmedchemlett.5c00390 (opens in new tab)

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AI-extracted from the abstract
Characteristics Peer reviewed
Topics Addiction Depression PTSD
Key points The abstract claims novel phenethylamines that act as 5-HT2A agonists and proposes their use in pharmaceutical compositions for treating depression, drug addiction, alcoholism, PTSD, and neuropathic pain, without reporting any experimental or clinical results.

Abstract

Provided herein are novel phenethylamines as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating depression, drug addiction, alcoholism, post-traumatic stress disorder (PTSD) and neuropathic pain, and processes for preparing such compounds.

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