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Esketamine for major depressive disorder: pharmacokinetics and toxicological considerations

Shreya Vasudeva, Gabrielle F. M. Lovell, Joshua Daniel Rosenblat

Expert Opinion on Drug Metabolism & Toxicology May 4, 2026 DOI: 10.1080/17425255.2026.2671066 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Peer reviewed
Topics Depression Esketamine

Abstract

1. Esketamine nasal spray was FDA-approved in 2019 for treatment-resistant depression (TRD; in conjunction with an oral antidepressant), with approval expanded to major depressive disorder (MDD) wi...

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