Gi Signaling Does Not Differentiate Hallucinogenic from Nonhallucinogenic 5-HT2A Receptor Agonists.
Cassandra J. Hatzipantelis, David E. Olson
ACS Chemical Neuroscience November 4, 2026 DOI: 10.1021/acschemneuro.6c00743 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary Peer reviewed |
|---|---|
| Topics | Serotonin |
| Keywords | 5-ht2ar Gi signaling Hallucinogen Psychedelic |
| Key points | Argues, based on a reanalysis of Xu et al.'s source data, that Gi activation is a weaker predictor of hallucinogenic potential than the canonical effectors of 5-HT2AR signaling, contrary to the original claim that Gi activation differentiates hallucinogenic from non-hallucinogenic agonists. |
Abstract
A recent publication by Xu et al. suggests that Gi activation following 5-HT2AR stimulation differentiates hallucinogenic from nonhallucinogenic agonists. Here, we reanalyze the author's source data to demonstrate that Gi activation is less predictive of hallucinogenic potential than canonical effectors of 5-HT2AR signaling.
Citations in the library
Cites 11
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- Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs ACS Chemical Neuroscience December 15, 2022
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