Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis
Marije E. Otto, Katelijne V. van der Heijden, Jan W. Schoones, Michiel J. van Esdonk, Laura Borghans, Gabriël E. Jacobs, J. G. Coen van Hasselt
Clinical Pharmacokinetics 2025 DOI: 10.1007/s40262-024-01454-4 (opens in new tab)
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Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Pharmacology Pharmacokinetics Post hoc |
| Citations | 20 |
| Key findings | Pharmacokinetic parameters of psilocin are consistent between studies. |
Abstract
Overall, we found the pharmacokinetic parameters of psilocin to be consistent between studies. This review may guide the further clinical development of psilocybin-based therapies.
Comparable studies
Other narrative reviews on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The pharmacology of psilocybin | 2002 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| Psychedelics, Meditation, and Self-Consciousness | 2018 | Review | |
| The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act | 2018 | Review |
Citations in the library
Cited by 18
- Pharmacokinetics of Psilocybin: A Systematic Review Pharmaceutics March 25, 2025
- The Potential Role of Psilocybin in Traumatic Brain Injury Recovery: A Narrative Review Brain Sciences May 26, 2025
- An exploration of the relationships between the effects of psilocybin on behavior, 5-HT 2A receptor occupancy, and neuroplastic effects in mice Journal of Psychopharmacology January 6, 2026
- Improved mental health outcomes and normalised spontaneous EEG activity in veterans reporting a history of traumatic brain injuries following participation in a psilocybin retreat Frontiers in Psychiatry August 6, 2025
- Psychedelics and women’s mental health: the effects of female sex hormones on psychedelics’ efficacy and tolerability Molecular Psychiatry August 4, 2026
and 13 more in the library
Cites 29
- Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Neuropsychopharmacology January 26, 2019
- Single-Dose Psilocybin Treatment for Major Depressive Disorder JAMA August 31, 2023
- Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors Science February 16, 2023
- The pharmacology of psilocybin Addiction Biology October 1, 2002
- Monoamine oxidase inhibitors in South American hallucinogenic plants: Tryptamine and β-carboline constituents of Ayahuasca Journal of Ethnopharmacology April 1, 1984
and 24 more in the library