Narcolepsy following cerebral hypoxic ischemia
Víctor M. Rivera, John Stirling Meyer, Takashi Hata, Yoshiki Ishikawa, Akira Imai
Annals of Neurology May 1, 1986 DOI: 10.1002/ana.410190516 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A 51-year-old man with non-HLA-DR2 histocompatibility who developed narcoleptic symptoms after cardiopulmonary insufficiency during anesthesia induction |
| Measures | polysomnographic examinations, cerebral blood flow measurement, magnetic resonance imaging |
| Citations | 54 |
| Key findings | A 51-year-old man without HLA-DR2 developed the classic narcoleptic tetrad after cardiopulmonary insufficiency during anesthesia induction, with the diagnosis confirmed by repeated polysomnography. Cerebral blood flow increased markedly during the onset of rapid-eye-movement sleep, resembling patterns previously reported in narcolepsy, and MRI showed focal abnormal spin-echo signals in the ventral pons. |
Abstract
A 51-year-old man with non-HLA-DR2 histocompatibility developed classic signs and symptoms of the narcoleptic tetrad soon after recovering from an episode of cardiopulmonary insufficiency, which occurred during induction of surgical anesthesia. Symptoms included excessive daytime sleepiness, hypnagogic hallucinations, sleep paralysis, and cataplexy. The diagnosis was confirmed by repeated polysomnographic examinations in the sleep laboratory. Cerebral hemodynamic changes during the onset of sleep showed remarkable increases of cerebral blood flow during the onset of rapid-eye-movement sleep similar to those reported previously in patients with narcolepsy. Magnetic resonance imaging showed focal regions of abnormal spin-echo signals in the ventral pons.