The atypical antipsychotic, remoxipride, blocks phencyclidine-induced disruption of prepulse inhibition in the rat.
C Johansson, D M Jackson, L Svensson
Psychopharmacology December 1994 DOI: 10.1007/bf02247475 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Haloperidol Clozapine Raclopride Remoxipride Phencyclidine (PCP) |
| Dose | Clozapine 4-40 µmol/kg; haloperidol 1-5 µmol/kg; raclopride 1-12 µmol/kg; remoxipride 12-60 µmol/kg |
| Measures | Prepulse inhibition (PPI) of the acoustic startle response |
| Key findings | Clozapine, haloperidol, and raclopride failed to reverse PCP-induced disruption of prepulse inhibition of the acoustic startle response in rats, whereas remoxipride produced a dose-dependent block of this effect. The authors conclude that remoxipride behaves in a unique way in this model compared with the other three antipsychotics. |
Abstract
The effect of various typical (haloperidol) and atypical (clozapine, raclopride, remoxipride) antipsychotics on phencyclidine (PCP)-induced disruption of sensorimotor gating was tested in rats using an acoustic startle paradigm. Clozapine (4-40 mumol/kg), haloperidol (1-5 mumol/kg) and raclopride (1-12 mumol/kg) failed to reverse PCP-induced disruption of prepulse inhibition (PPI) of the acoustic startle response. In contrast, remoxipride (12-60 mumol/kg) caused a dose-dependent block of this effect. PCP-induced disruption of PPI is a widely accepted animal model of a corresponding behavioural deficit observed in schizophrenia although little evidence has been presented that it is in fact sensitive to antipsychotic agents. The present results indicate that remoxipride behaves in a unique way in this model compared to clozapine, haloperidol and raclopride.
Citations in the library
Cited by 4
- Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine in Wistar rats. British Journal of Pharmacology 2022
- The neuronal selective nitric oxide inhibitor AR-R 17477, blocks some effects of phencyclidine, while having no observable behavioural effects when given alone. Pharmacology & Toxicology May 1, 1999
- Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity. Reviews in the Neurosciences 1999
- Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine. Psychopharmacology November 1995
Cites 2
- Recent advances in the phencyclidine model of schizophrenia American Journal of Psychiatry October 1, 1991
- A comparison between classes of drugs having phencyclidine-like behavioral properties on dopamine efflux in vitro and dopamine metabolism in vivo. Journal of Pharmacology and Experimental Therapeutics November 1, 1984