Cannabidiol attenuates delta 9-tetrahydrocannabinol-like discriminative stimulus effects of cannabinol.
A J Hiltunen, Torbjörn U C Järbe
European Journal of Pharmacology June 17, 1986 DOI: 10.1016/0014-2999(86)90042-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Drug discrimination study in rats Peer reviewed |
|---|---|
| Population | Rats trained to discriminate delta 9-THC from vehicle |
| Interventions | Cannabinol (CBN) Cannabidiol (CBD) delta 9-tetrahydrocannabinol (delta 9-THC) |
| Dose | 3 mg/kg delta 9-THC (training dose); 2 ml/kg vehicle |
| Topics | Cannabis CBD |
| Key points | CBN's generalization to the delta 9-THC cue was attenuated when CBN was co-administered with CBD, and the authors report that these interaction effects were time- and dose-dependent. |
Abstract
Interaction effects of cannabidiol (CBD) and cannabinol (CBN) were examined using a drug discrimination procedure in which rats had been trained to discriminate between 3 mg/kg of delta 9-tetrahydrocannabinol (delta 9-THC) and vehicle (2 ml/kg). The generalization effects of CBN to delta 9-THC were attenuated when CBN was administered together with CBD. The results were time- and dose-dependent.
Comparable studies
Other preclinical and animal studies on CBD, most cited first.
Citations in the library
Cited by 2
Cites 3
- Interactions between delta 9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons. Neuropharmacology February 1986
- Interactions in man of delta-9-tetrahydrocannabinol. II. Cannabinol and cannabidiol. Clinical Pharmacology & Therapeutics July 1975
- Effects of marihuana in laboratory animals and in man. British Journal of Pharmacology February 1974