Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane.
Peyton Jacob, G Anderson, C K Meshul, Alexander T. Shulgin, N Castagnoli
Journal of Medicinal Chemistry October 1977 DOI: 10.1021/jm00220a001 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Rabbits (hyperthermia assay) and rats (brain concentration studies) |
| Interventions | Monomethylthio analogues of 1-(2 4 5-trimethoxyphenyl)-2-aminopropane |
| Measures | Rabbit hyperthermia assay |
| Key points | Describes regiospecific syntheses of three monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane and their evaluation for potential psychotomimetic potency in the rabbit hyperthermia assay, with enantiomeric composition and rat brain time-concentration curves determined after intraperitoneal administration. The biological data are compared with results for the potent human psychotogen DOM, but the abstract states no specific potency or concentration outcomes. |
Abstract
Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric compositions and time-concentration curves in rat brains were determined following intraperitoneal administration of each compound. The biological data are contrasted with the corresponding results obtained with the potent human psychotogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM).