2,5-Dimethoxy-4-methylamphetamine (DOM)- a central component of its cardiovascular effects in rats; involvement of serotonin.
E Friedman, G A Lambert, E Buchweitz
European Journal of Pharmacology May 15, 1978 DOI: 10.1016/0014-2999(78)90072-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Anesthetized rats |
| Interventions | DOM hexamethonium 5-HT |
| Topics | Serotonin |
| Key findings | Argues that DOM's rise in blood pressure and heart rate is mediated by direct stimulation of central serotonin (5-HT) receptors, based on abolition by spinal cord transection, reduction by centrally but not peripherally given BOL, and lack of effect of hexamethonium. Reports that tachyphylaxis develops rapidly and coincides with reduced 5-HT-induced central cardiovascular response, possibly from irreversible DOM binding or receptor desensitization. |
Abstract
The hallucinogen DOM produces a rise in blood pressure and heart rate when injected into the cerebral ventricles of anesthetized rats. These effects are abolished in rats with transected spinal cords but are unaffected by prior treatment with hexamethonium. Central but not peripheral administration of the serotonin antagonist BOL reduces the response. Tachyphylaxis to the response develops rapidly and is accompanied by a decrease in the ability of 5-HT to induce a centrally mediated cardiovascular change. It is concluded that the response is mediated by direct stimulation of central 5HT receptors. Tachyphylaxis may be the result of irreversible binding of DOM to 5-HT receptors or to 5-HT receptor densensitization.
Comparable studies
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| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |