Stereochemical considerations of the actions of some psychotropic drugs.
D F Smith
Pharmacopsychiatry May 1985 DOI: 10.1055/s-2007-1017370 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Key findings | Argues that studies using enantiomers, geometrical isomers, and semi-rigid molecules show that three-dimensional spatial features play a role in the effects of antidepressant, antipsychotic, antiparkinsonian, antianxiety, stimulant, and psychotomimetic drugs, and that understanding this role might help reduce side effects and enhance therapeutic efficacy. |
Abstract
Stereoisomers have been used as tools to investigate the role of spatial (3-dimensional) features in neurochemical and behavioral effects of psychotropic drugs. Studies using enantiomers (optical isomers), geometrical isomers and semi-rigid molecules have shown that spatial features play a role in effects of antidepressant, antipsychotic, antiparkinsonian, and antianxiety drugs, as well as stimulants and psychotomimetics. An understanding of the role of spatial features in effects of psychotropic drugs might aid in reducing their side effects and in enhancing their therapeutic efficacy.