Cannabinoid Modulation of the Stressed Hippocampus.
Franciele F Scarante, Carla Vila-Verde, Vinícius L Detoni, Nilson C Ferreira-Junior, Francisco S Guimarães, Alline C. Campos
Frontiers in Molecular Neuroscience December 19, 2017 DOI: 10.3389/fnmol.2017.00411 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Neuroplasticity |
| Keywords | Stress Hippocampus Hpa axis Cb2 Cb1 Endocannabinoid system |
| Key findings | The authors argue that hippocampal endocannabinoid signaling helps regulate excitatory and inhibitory neurotransmission and neuroplasticity, and that facilitating cannabinoid signaling in this region may prevent stress-induced behavioral changes. They also note that chronic stress modulates hippocampal CB1 receptor expression and endocannabinoid levels, and that cannabinoids participate in synaptic plasticity and adult neurogenesis. |
Abstract
Exposure to stressful situations is one of the risk factors for the precipitation of several psychiatric disorders, including Major Depressive Disorder, Posttraumatic Stress Disorder and Schizophrenia. The hippocampal formation is a forebrain structure highly associated with emotional, learning and memory processes; being particularly vulnerable to stress. Exposure to stressful stimuli leads to neuroplastic changes and imbalance between inhibitory/excitatory networks. These changes have been associated with an impaired hippocampal function. Endocannabinoids (eCB) are one of the main systems controlling both excitatory and inhibitory neurotransmission, as well as neuroplasticity within the hippocampus. Cannabinoids receptors are highly expressed in the hippocampus, and several lines of evidence suggest that facilitation of cannabinoid signaling within this brain region prevents stress-induced behavioral changes. Also, chronic stress modulates hippocampal CB1 receptors expression and endocannabinoid levels. Moreover, cannabinoids participate in mechanisms related to synaptic plasticity and adult neurogenesis. Here, we discussed the main findings supporting the involvement of hippocampal cannabinoid neurotransmission in stress-induced behavioral and neuroplastic changes.
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Citations in the library
Cites 8
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Science August 19, 2010
- Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis Proceedings of the National Academy of Sciences December 13, 2005
- Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB₁R signaling and anxiety-like behavior. Journal of Neurochemistry November 2015
- The Role of Cannabinoids in Modulating Emotional and Non-Emotional Memory Processes in the Hippocampus Frontiers in Behavioral Neuroscience June 7, 2011
- Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus. Neuropharmacology 2010
and 3 more in the library