Functional diversity on synaptic plasticity mediated by endocannabinoids.
Roger Cachope
Philosophical transactions of the Royal Society of London. Series B, Biological sciences December 5, 2012 DOI: 10.1098/rstb.2011.0386 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Neuroplasticity |
| Key findings | The review characterizes the endocannabinoid system—cannabinoid receptors, ligands, and enzymes—as the best-described retrograde signaling system in the brain. It argues that eCB-mediated modulation of synaptic transmission is widespread and more diverse than initially thought, and that specializations of this signaling system produce a multiplicity of effects at the circuit level. |
Abstract
Endocannabinoids (eCBs) act as modulators of synaptic transmission through activation of a number of receptors, including, but not limited to, cannabinoid receptor 1 (CB1). eCBs share CB1 receptors as a common target with Δ(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient in marijuana. Although THC has been used for recreational and medicinal purposes for thousands of years, little was known about its effects at the cellular level or on neuronal circuits. Identification of CB1 receptors and the subsequent development of its specific ligands has therefore enhanced our ability to study and bring together a substantial amount of knowledge regarding how marijuana and eCBs modify interneuronal communication. To date, the eCB system, composed of cannabinoid receptors, ligands and the relevant enzymes, is recognized as the best-described retrograde signalling system in the brain. Its impact on synaptic transmission is widespread and more diverse than initially thought. The aim of this review is to succinctly present the most common forms of eCB-mediated modulation of synaptic transmission, while also illustrating the multiplicity of effects resulting from specializations of this signalling system at the circuital level.
Comparable studies
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| Study | Year | Design | Participants |
|---|---|---|---|
| A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists | 2012 | Review | |
| Towards an understanding of psychedelic-induced neuroplasticity. Review of preclinical and clinical studies | 2023 | Review | |
| Buddha's Brain: Neuroplasticity and Meditation [In the Spotlight] | 2008 | Review | |
| Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics | 2021 | Review | |
| Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms | 2020 | Review |
Citations in the library
Cited by 3
- Possible therapeutic applications of cannabis in the neuropsychopharmacology field. European Neuropsychopharmacology July 2020
- Delta-9-tetrahydrocannabinol potentiates fear memory salience through functional modulation of mesolimbic dopaminergic activity states. European Journal of Neuroscience June 2018
- Cortical thinness and volume differences associated with marijuana abuse in emerging adults. Drug and Alcohol Dependence October 1, 2015
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