Role of NMDA receptor GluN2D subunit in the antidepressant effects and the cognitive impairment effects of enantiomers of ketamine
Soichiro Ide, Yuiko Ikekubo, Masayoshi Mishina, Kenji Hashimoto, Kazutaka Ikeda
Proceedings for Annual Meeting of The Japanese Pharmacological Society 2018 DOI: 10.1254/jpssuppl.wcp2018.0_po3-1-15 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Intervention | Ketamine |
| Topics | Esketamine Ketamine |
| Key points | States that ketamine, a racemic mixture of equal amounts of (R)-ketamine and (S)-ketamine, exerts rapid and sustained antidepressant effects in depressed patients, and that the neural mechanisms behind the differing effects of the two enantiomers remain unclear. |
Abstract
Background: The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine exerts rapid and sustained antidepressant effects in depressed patients. Ketamine is a racemic mixture of equal amounts of enantiomers, (R)-ketamine and (S)-ketamine. The neural mechanisms that underlie different effects of these enantiomers remain unclear.