Uji Efek Antidepresan Ekstrak Metanol Jamur Tlethong (Psilocybe cubensis) Pada Tikus Putih Jantan (Rattus norvegicus): ditinjau dari Immobility Time Dengan Metode Forced Swim Test
Nofri P. Kurama, Widdhi Bodhi, Weny Wiyono
PHARMACON August 1, 2013 DOI: 10.35799/pha.2.2013.2328 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | White male Wistar rats (Rattus norvegicus) |
| Dose | 500 mg/kgBB, 625 mg/kgBB, 750 mg/kgBB |
| Measures | immobility time (forced swim test, tail suspension test) |
| Citations | 4 |
| Key findings | The abstract reports that Tlethong (Psilocybe cubensis) extract showed antidepressant activity, assessed by immobility time in the forced swim test, in male Wistar rats. No numerical results, effect sizes, or statistical outcomes are reported in the text. |
Abstract
ABSTRACTTlethong mushroom (Psilocybe cubensis) contains psilocybin that potential as antidepressant.The aim of this research was to examine the effect of Tlethong extract as antidepressant onwhite male wistar (Rattus norvegicus). Antidepressant test were evaluate on white malewistar which divided into 5 groups. The first group were administered with aquadest asnegative control, Second group were administered with amitriptilin as positive control, thirdgroup were administered with Tlethong extract with dose 500 mg/KgBB, 625 mg/KgBB and750 mg/KgBB then tail suspension test were conducted. Immobility time dengan metodeforced swim test. Obtained data were analyzed by one way ANOVA. The result shows thatTlethong extract possess antidepressant activity evaluated by its immobility time using forcedswim test method.Keywords: Antidepressant, immobility time, forced swim test, tail suspension test, Psilocybecubensis