Cannabis sativa use in adolescence and risk of psychosis: a systematic review / Uso de cannabis sativa na adolescência e risco de psicose: uma revisão sistemática
Marina Bertoldo Baeza, Ricardo S. S. Durães, Antonio de Pádua Serafim
Brazilian Journal of Health Review 2021 DOI: 10.34119/bjhrv4n2-079 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Sample size | 81,049 |
| Population | Participants in the 32 original studies on adolescent cannabis use and psychosis |
| Topics | Cannabis |
| Key findings | The authors report that 97.3% of the 32 included studies indicated an association between early cannabis use and onset of psychosis, across 81,049 total participants. They suggest that early use combined with genetic vulnerability, gender, duration of use, environmental and social factors, or other drug use may contribute to later schizophrenia compared with non-users, while cautioning that other social and biological variables should be considered. |
Abstract
Background: Studies have pointed out the increased risk of developing psychosis in adulthood related to cannabis use during adolescence.Aim: To conduct a systematic review of the literature on the use of cannabis in adolescence and risk of psychosis.Method: We conducted a systematic review in accordance with PRISMA guidelines.We searched by PubMed, PsycINFO, and SciELO database between 2010 and 2019.Results: After an accurate analysis, of the 8.673 records screened articles, we selected and included 32 original studies in this systematic review.The sample in the original papers totaled 81.049 participants, indicating an association between early use of cannabis and the onset of psychosis in 97.3% of the studies, with a robust variety of instruments used.It has been shown that early cannabis use, associated to genetic vulnerability, gender, duration of use, environmental and social factors, or the use of other drugs may lead to late development of schizophrenia whether compared with non-users.Conclusion: There is evidence that marijuana use is associated with the occurrence of psychosis in adolescence and later in life.However, other variables, such as social and biological aspects, should be considered.This shows the importance of educational programs of public policies on risks of cannabis and clear information to the population about several combination factors that might lead to trigger psychotic disorders, such as schizophrenia.
Comparable studies
Other systematic reviews and meta-analyses on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Effects of cannabis use on outcomes of psychotic disorders: systematic review People with psychotic disorders, as examined in 13 longitudinal studies | 2008 | Systematic review | |
| The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample Patients with established schizophrenia (meta-analysis: 572) and patients with... | 2010 | Meta-analysis and cross-sectional observational study | n = 700 |
| Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review | 2020 | Systematic review | |
| Neuroimaging in cannabis use: a systematic review of the literature Cannabis users and controls in neuroimaging studies | 2009 | Systematic review | |
| Human Laboratory Studies on Cannabinoids and Psychosis. Healthy human subjects and individuals with schizophrenia | 2016 | Systematic review |