UNRAVELLING THE ROLE OF 5-HT2AR ACTIVATION IN THE LONG-LASTING BEHAVIORAL EFFECTS OF PSILOCYBIN
Chloé Galipeau, Miguel Farinha‐ferreira, Jean-Charles Rene’ Pasquin Mariani, Samuel Diebolt, Louis Barthe, Renata Santos, Zsolt Lenkei, Ana Maria Sebastião
IBRO Neuroscience Reports October 1, 2023 DOI: 10.1016/j.ibneur.2023.08.1116 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Interventions | Psilocybin MDL100907 Lisuride |
| Topics | Psilocybin |
| Key points | The text proposes to test whether 5-HT2A receptor activation is necessary and/or sufficient for psilocybin's persisting behavioral effects, using the antagonist MDL100907 and the non-psychedelic agonist lisuride. No results are reported in the abstract. |
Abstract
Psilocybin is a 5-HT2AR agonist, responsible for the psychoactive effects of psychedelic mushrooms, which has recently shown therapeutic potential for several conditions, including major depressive disorder. However, the mechanisms underlying this effect, and the possibility of dissociating the psychedelic and antidepressant actions of psilocybin, remain undetermined, with preclinical research being necessary to answer these questions. Here, we aimed to assess if 5-HT2AR activation is necessary and/or sufficient for the persisting behavioral actions of psilocybin, using the 5-HT2AR antagonist MDL100907, and lisuride, a non-psychedelic 5-HT2AR and D2R agonist.
Comparable studies
Other preclinical and animal studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice Mice | 2021 | Experimental study | |
| Psychedelics reopen the social reward learning critical period Mice | 2023 | Experimental study in mice | |
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning Mice | 2013 | Experimental study |