Defining the Intervention Before Estimating Efficacy in DMT-Assisted Therapy (Accepted Manuscript)
Kenjiro Shiraishi
Zenodo (CERN European Organization for Nuclear Research) September 18, 2026 preprint DOI: 10.5281/zenodo.22821320 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary |
|---|---|
| Topics | DMT |
| Key points | Argues that DMT-assisted therapy for substance misuse should be evaluated as a complex intervention rather than as pharmacological exposure alone, and that efficacy estimates and future systematic reviews should distinguish pharmacological exposure, psychological or integration processes, contextual or ceremonial elements, and safety and ethical safeguards. |
Abstract
Accepted manuscript of:Shiraishi K. Defining the Intervention Before Estimating Efficacy in DMT-Assisted Therapy. Journal of Psychopharmacology. 2026.DOI: 10.1177/02698811261488484 This Letter argues that DMT-assisted therapy for substance misuse should be evaluated as a complex intervention rather than as pharmacological exposure alone. It highlights the need to distinguish pharmacological exposure, psychological or integration processes, contextual or ceremonial elements, and safety/ethical safeguards when interpreting efficacy estimates and designing future systematic reviews. This is the author accepted manuscript, following peer review and prior to publisher typesetting. The Version of Record is available from the Journal of Psychopharmacology via the DOI above.
In the evidence
This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.
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State of the evidence: DMT Unclear
Argues that DMT-assisted therapy for substance misuse should be evaluated as a complex intervention distinguishing pharmacological exposure, psychological integration, contextual elements, and safety safeguards.
Synthesized