Enantioselektive Gewinnung und Kristallstruktur des Ecstasy-Analogons N-Ethyl-3,4-methylendioxyamphetamin-HCl (MDE) und seiner beiden Hauptmetaboliten MDA und HME / Enantioselective Production and Crystal Structure of the Ecstasy Analogue N-Ethyl-3,4- methylenedioxyamphetamine-HCl (MDE) and its Major Metabolites MDA and HME
The authors report a synthetic route to pure enantiomers of MDE and its metabolites MDA and HME, and present their crystal and molecular structures from X-ray crystallography. They state that hydrogen bonding in the crystal lattice differs significantly between (R)- and (S)-MDA-HCl.
Abstract
A synthetic route to the production of the pure enantiomers of the ecstasy-analogue N-Ethyl- 3,4-methylenedioxyamphetamine (MDE) and its major metabolites MDA and HME is presented. The crystal and molecular structure of these compounds has been determined by X-ray crystallography. The hydrogen bonding in the crystal lattice is examined and significant differences were found by comparing (R)- and (S)-MDA-HCl.