Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy: potential clinical implications.
Dragoš Inta, Massimo Trusel, Marco A Riva, Rolf Sprengel, Peter Gass
The International Journal of Neuropsychopharmacology September 2009 DOI: 10.1017/s1461145709990319 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Intervention | Ketamine |
| Key points | Reports that NMDA receptor antagonists, including a single intravenous ketamine injection, can produce rapid and relatively sustained antidepressant effects in patients, and that the role of NMDA receptors and their signaling pathways in depression pathophysiology and therapy is under intense research. |
Abstract
Preclinical and clinical studies have shown that N-methyl-D-aspartate (NMDA) receptor antagonists can exert antidepressant effects. Thus, a single intravenous injection of ketamine, a non-competitive NMDA receptor antagonists, has been recently demonstrated to produce a rapid and relatively sustained antidepressant effect in patients. Therefore, the role of NMDA receptors and their signalling pathways for pathophysiology and therapy of depression are under intense research.
Citations in the library
Cited by 5
- Comparative Brain-Wide Mapping of Ketamine and Isoflurane-Activated Nuclei and Functional Networks bioRxiv Preprint Server June 3, 2023
- Discrimination of motor and sensorimotor effects of phencyclidine and MK-801: Involvement of GluN2C-containing NMDA receptors in psychosis-like models. Neuropharmacology August 1, 2022
- Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine Translational Psychiatry December 1, 2020
- Role of the nitric oxide donor sodium nitroprusside in the antidepressant effect of ketamine in mice. European Neuropsychopharmacology October 1, 2015
- Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment. Journal of Neuroscience October 3, 2012
Cites 4
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