Modulatory effects of low-dose MDMA on cocaine-induced locomotor activity and place conditioning in rats.
Pharmacology, Biochemistry, and Behavior January 2012 DOI: 10.1016/j.pbb.2011.09.007 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled experimental animal study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | MDMA Cocaine |
| Dose | MDMA 1.5 or 3.0 mg/kg; cocaine 10 or 20 mg/kg |
| Topics | MDMA |
| Key findings | Low-dose MDMA (1.5 mg/kg) enhanced the locomotor and conditioned rewarding effects of cocaine in rats, as measured by conditioned place preference. The authors suggest these results may have implications for understanding serotonergic-dopaminergic interactions in the abuse liability of MDMA combined with cocaine or other psychostimulants. |
Abstract
Methylenedioxymethamphetamine (MDMA; "Ecstasy") is commonly abused by humans in environments such as nightclubs and rave parties where other drugs of abuse are readily available. Despite the popularity of polysubstance abuse among recreational MDMA users, relatively few controlled experimental studies have documented the neurobehavioral effects of MDMA in combination with other abused substances. This study employed conditioned place preference procedures (CPP) to assess the locomotor activating and place conditioning effects of acute concurrent administration of MDMA (1.5 or 3.0 mg/kg) and cocaine (10 or 20 mg/kg) in rats. Results indicate that low dose MDMA can enhance the locomotor and conditioned rewarding effects of cocaine. These findings may have important implications for understanding the contribution of serotonergic-dopaminergic interactions in the abuse liability of MDMA when used in combination with cocaine or other psychostimulant drugs.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 2
- Use and abuse of dissociative and psychedelic drugs in adolescence Pharmacology, Biochemistry, and Behavior January 27, 2021
- Locomotor sensitization in male Sprague-Dawley rats following repeated concurrent treatment with 4-methylmethcathinone and 3,4-methylenedioxymethamphetamine Behavioural Pharmacology October 1, 2019
Cites 9
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- Enhancement of conditioned place preference response to cocaine in rats following subchronic administration of 3,4-methylenedioxymethamphetamine (MDMA) Synapse February 1, 2000
- PRECLINICAL STUDY: Acquisition and reinstatement of MDMA‐induced conditioned place preference in mice pre‐treated with MDMA or cocaine during adolescence Addiction Biology September 8, 2009
- Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine and its enantiomers in mice: pharmacokinetic considerations. Journal of Pharmacology and Experimental Therapeutics June 2009
- Acute behavioural and neurotoxic effects of MDMA plus cocaine in adolescent mice. Neurotoxicology and Teratology 2009
and 4 more in the library