Involvement of 5-hydroxytryptamine neuronal system in Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory.
Nobuaki Egashira, Kenichi Mishima, Shutaro Katsurabayashi, Tomohiro Yoshitake, Yoshiaki Matsumoto, Junichi Ishida, Masatoshi Yamaguchi, Katsunori Iwasaki, Michihiro Fujiwara
European Journal of Pharmacology June 12, 2002 DOI: 10.1016/s0014-2999(02)01755-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical animal study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Delta(9)-tetrahydrocannabinol clomipramine 5-methoxy-N 1-(2 |
| Dose | Delta(9)-tetrahydrocannabinol 6 mg/kg, i.p.; 5-HTP 50 mg/kg, i.p.; clomipramine 0.01 and 0.1 mg/kg, i.p.; 5-MeODMT 0.01 and 0.03 mg/kg, i.p.; DOI 10 microg/kg, i.p. |
| Measures | eight-arm radial maze, microdialysis |
| Topics | Cannabis |
| Key points | Delta-9-tetrahydrocannabinol (6 mg/kg) impaired spatial memory in the eight-arm radial maze while increasing serotonin content and decreasing serotonin release in the ventral hippocampus. Agents that enhance serotonergic signaling (5-HTP, clomipramine, 5-MeODMT, DOI) attenuated the memory impairment, suggesting the serotonin system may be involved in THC-induced spatial memory deficits. |
Abstract
The present study investigated the involvement of the serotonin (5-hydroxytryptamine, 5-HT) neuronal system in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory in the eight-arm radial maze in rats. Delta(9)-Tetrahydrocannabinol (6 mg/kg, i.p.), which impairs spatial memory, significantly increased the 5-HT content in the ventral hippocampus. A microdialysis study showed that Delta(9)-tetrahydrocannabinol (6 mg/kg, i.p.) decreased 5-HT release in the ventral hippocampus. The 5-HT precursor, 5-hydroxy-L-tryptophan (5-HTP; 50 mg/kg, i.p.), the 5-HT re-uptake inhibitor, clomipramine (0.01 and 0.1 mg/kg, i.p.), the 5-HT receptor agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT; 0.01 and 0.03 mg/kg, i.p.), and the 5-HT(2) receptor agonist, 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane (DOI; 10 microg/kg, i.p.), significantly attenuated the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory. These results suggest that the 5-HT neuronal system may be involved in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.
Citations in the library
Cited by 6
- A narrative synthesis of research with 5-MeO-DMT. Journal of Psychopharmacology March 1, 2022
- The Potential of Cannabidiol for the Treatment of Psychosis: Endocannabinoid Regulation of Serotonergic Neurotransmission via Serotonin 5-HT1A/2A Receptors. Neurochemical Research August 27, 2026
- Neuroimaging studies of acute effects of THC and CBD in humans and animals: a systematic review. Current Pharmaceutical Design 2014
- Involvement of opioid system in cognitive deficits induced by ∆⁹-tetrahydrocannabinol in rats. Psychopharmacology February 2012
- Delta 9-tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons. Neuroscience January 24, 2008
and 1 more in the library
Cites 5
- Do functional relationships exist between 5-HT1A and 5-HT2 receptors? Pharmacology, Biochemistry, and Behavior August 1, 1990
- Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat European Journal of Pharmacology October 1, 1985
- The effects of 8-hydroxy-2-(di-n-propylamino)tetralin and other serotonergic agonists on performance in a radial maze: a possible role for 5-HT1A receptors in memory. Pharmacology, Biochemistry, and Behavior August 1, 1987
- Delta 9-tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism. Psychopharmacology July 1996
- Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats. Psychopharmacology June 1995