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Effect of Yoga Intervention for Health Care Workers During the COVID-19 Pandemic: A Systematic Review.

I-Jung Chen, Yuan-Sheng Tzeng, Shu-Yu Wu, Fong-Ching Chang

Journal of Integrative and Complementary Medicine July 2026 DOI: 10.1177/27683605261419365 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Systematic review Randomized Peer reviewed
Population Health care workers in India, Turkey, and the United States during the COVID-19 pandemic
Interventions Yoga Tailored yoga protocols
Duration Intervention durations ranged from 2 to 12 weeks
Topics Depression
Keywords Covid-19 Health care workers Systematic review Yoga
Key findings Across 11 included studies, yoga interventions consistently reduced stress, anxiety, and depression and improved sleep quality and quality of life among health care workers, with additional physiological benefits such as enhanced autonomic function and reduced inflammatory markers. The authors conclude that yoga is a valuable holistic support for health care workers in high-stress environments, while noting the overall quality of the included studies was moderate.

Abstract

Health care workers (HCWs) faced unprecedented stress, anxiety, and burnout during the COVID-19 pandemic. Yoga, a mind-body practice combining physical postures, breathing, and meditation, has demonstrated benefits for mental and physical resilience. This systematic review evaluated the effectiveness of yoga interventions in addressing mental health challenges and promoting overall well-being among HCWs during the pandemic. This review adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Comprehensive searches of PubMed, EMBASE, and Cochrane CENTRAL were conducted up to November 2024 using terms including "yoga," "COVID-19," and "health care workers." Eligible studies involved HCWs receiving yoga interventions compared with nonyoga controls. Outcomes included stress, anxiety, depression, sleep quality, and physiological parameters. Randomized controlled trials, cohort studies, and observational studies were included. Quality assessment was performed using the Cochrane Risk of Bias Tool (RoB 1.0). Certainty of evidence assessment was conducted with Grading of Recommendations Assessment, Development and Evaluation. Of 134 studies identified, 11 met the inclusion criteria. Participants included HCWs from India, Turkey, and the United States, with intervention durations ranging from 2 to 12 weeks. Yoga consistently reduced stress, anxiety, and depression, with improvements in sleep quality and quality of life. Physiological benefits included enhanced autonomic function and reduced levels of inflammatory markers. App-based and tailored yoga protocols showed potential for scalability and accessibility. The overall quality of the included studies was moderate. Yoga interventions demonstrated significant benefits in mitigating mental health challenges and enhancing overall well-being in HCWs during the COVID-19 pandemic. These findings underscore the value of yoga as a holistic support for HCWs in high-stress environments.

Comparable studies

Other systematic reviews and meta-analyses on depression, most cited first.

Study Year Design Participants
Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression Participants with major depression in placebo-controlled, double-blind, randomized... 2015 Systematic review and meta-analysis
Side-effects associated with ketamine use in depression: a systematic review. Patients with depression 2018 Systematic review
Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis Adults with unipolar or bipolar major depression 2020 Systematic review and meta-analysis n = 1,877
Single-dose infusion ketamine and non-ketamine N-methyl-D-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories Patients with major depressive disorder or bipolar depression 2016 Systematic review and meta-analysis n = 588
Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies Patients with cancer- or illness-related anxiety and depression, major depressive... 2020 Systematic review n = 188

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