Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).
Chelsea R Kasten, Yanping Zhang, Ken Mackie, Stephen L Boehm
Behavior genetics May 2018 DOI: 10.1007/s10519-018-9894-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Selective breeding study Peer reviewed |
|---|---|
| Population | Adolescent mice |
| Intervention | THC |
| Dose | 10 mg/kg |
| Topics | Cannabis |
| Keywords | Adolescent Cannabinoids Genetic Locomotion Selection |
| Key points | Selective breeding for sensitivity to THC's locomotor effects in adolescent mice produced a moderate heritable response, with the greatest heritability estimates in females from the F2 to S3 generations. Selection for locomotor sensitivity also led to increased anxiety-like activity in the open field. The authors state this is the first evidence that adolescent THC-locomotor sensitivity can be influenced by selective breeding. |
Abstract
Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single 10 mg/kg THC dose in the open field. Selection for THC-locomotor sensitivity was moderately heritable, with the greatest estimates of heritability seen in females from the F2 to S3 generations. Selection for locomotor sensitivity also resulted in increased anxiety-like activity in the open field. These results are the first to indicate that adolescent THC-locomotor sensitivity can be influenced via selective breeding. Development of lines with a genetic predisposition for THC-sensitivity or resistance to locomotor effects allow for investigation of risk factors, differences in consequences of THC use, identification of correlated behavioral responses, and detection of genetic targets that may contribute to heightened cannabinoid sensitivity.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.
Citations in the library
Cited by 2
Cites 7
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