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Aberrant default mode network in amnestic mild cognitive impairment: a meta-analysis of independent component analysis studies.

ChunLei Wang, Yuan Pan, YanMei Liu, Ke Xu, LanXiang Hao, Fei Huang, Juan Ke, LiQin Sheng, HaiRong Ma, WeiFeng Guo

Neurological Sciences March 6, 2018 DOI: 10.1007/s10072-018-3306-5 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Meta-analysis Peer reviewed
Sample size 1,121
Population Patients with amnestic mild cognitive impairment and healthy controls from resting-state functional MRI studies
Topics Default mode network
Keywords Neural pathways Humans Amnesia Magnetic resonance imaging Brain mapping Cognitive dysfunction Independent component analysis Resting-State Functional MRI Seed-based d mapping
Key findings Patients with amnestic mild cognitive impairment showed lower default mode network functional connectivity than healthy controls in the bilateral precuneus/posterior cingulate cortices and medial temporal lobes. An exploratory meta-regression indicated that greater global cognitive impairment was associated with stronger connectivity in medial frontal cortices, left angular gyrus, and right temporal pole/middle temporal gyrus, which the authors suggest may reflect a compensatory mechanism.

Abstract

Independent component analysis (ICA) is one of the most popular and valid methods to investigate the default mode network (DMN), an intrinsic network which attracts particular attention in amnestic mild cognitive impairment (aMCI). However, previous studies present inconsistent results regarding the topographical organization of the DMN in aMCI. Therefore, we conducted a quantitative, voxel-wise meta-analysis of resting-state ICA studies using Seed-based d Mapping to establish the most consistent pattern of DMN functional connectivity alterations in aMCI. Twenty studies, comprising 23 independent datasets involving 535 patients and 586 healthy controls, met the inclusion criteria. Patients with aMCI exhibited reliably lower DMN functional connectivity than the healthy controls in the bilateral precuneus/posterior cingulate cortices and medial temporal lobes, which are implicated in episodic memory deficits. Moreover, an exploratory meta-regression analysis revealed that greater severity of global cognitive impairment in the patient groups was associated with stronger functional connectivity in the bilateral medial frontal cortices (including the anterior cingulate cortices), left angular gyrus, and right temporal pole extending to the middle temporal gyrus, likely reflecting a compensatory mechanism for maintaining cognitive efficiency. This meta-analysis identifies a consistent pattern of aberrant DMN functional connectivity in aMCI, which facilitates understanding of the neurobiological substrates of this disease.

Comparable studies

Other systematic reviews and meta-analyses on default mode network, most cited first.

Study Year Design Participants
The wandering brain: Meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes 2015 Meta-analysis
Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling 2009 Meta-analysis
The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis Healthy individuals 2016 Systematic review and meta-analysis
Dreaming as mind wandering: evidence from functional neuroimaging and first-person content reports. 2013 Systematic review with meta-analytic comparison
Default Mode Network Modulation by Psychedelics: A Systematic Review Participants from included studies 2022 Systematic review

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