Effects of Semax on the Default Mode Network of the Brain.
I S Lebedeva, Ya R Panikratova, O Yu Sokolov, D A Kupriyanov, A D Rumshiskaya, N V Kost, N F Myasoedov
Bulletin of experimental biology and medicine September 2018 DOI: 10.1007/s10517-018-4234-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Placebo-controlled experimental study Peer reviewed |
|---|---|
| Sample size | 24 |
| Population | Healthy volunteers (11 men and 13 women, aged 43.9±9.5 years) |
| Interventions | Semax placebo |
| Dose | 1% Semax |
| Duration | Resting-state fMRI before and 5 and 20 minutes after administration |
| Measures | resting state functional magnetic-resonance imaging (resting state fMRI) |
| Topics | Default mode network |
| Keywords | Semax Brain |
| Key findings | Intranasal 1% Semax was associated with a greater volume of the rostral (medial frontal cortex) subcomponent of the default mode network compared with placebo in healthy volunteers. The authors state that resting-state fMRI confirms Semax effects on the brain's neuronal network and demonstrates the topography of these effects. |
Abstract
The effects of nootropic drug Semax on the neuronal network of the brain were studied by the resting state functional magnetic-resonance imaging (resting state fMRI). The study was carried out on two groups of healthy volunteers (11 men and 13 women aged 43.9±9.5 years). Resting state fMRI was carried out 3 times: directly before and 5 and 20 min after intranasal 1% Semax (14 subjects) or placebo (10 subjects). The topography of the resting state default mode network was studied. A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls. Resting state fMRI confirmed Semax effects on the neuronal network of the brain and demonstrated topography of these effects.
Comparable studies
Other randomized controlled trials on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin Healthy volunteers | 2012 | Within-subjects, placebo-controlled, task-free fMRI study | n = 30 |
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| Ketamine Decreases Resting State Functional Network Connectivity in Healthy Subjects: Implications for Antidepressant Drug Action Healthy subjects | 2012 | Randomized, placebo-controlled, double-blind, crossover rsfMRI challenge | |
| Antidepressants Normalize the Default Mode Network in Patients With Dysthymia Subjects with dysthymic disorder and healthy control participants aged 18 to 53 years | 2013 | Randomized controlled trial | n = 41 |
| Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis Healthy volunteers | 2012 | Within-subject, placebo-controlled experimental study | n = 15 |