Neuromolecular basis of faded perception associated with unreality experience
Keita Yokokawa, Takehito Ito, Keisuke Takahata, Harumasa Takano, Yasuyuki Kimura, Masanori Ichise, Yoko Ikoma, Ayako Isato, Ming‐Rong Zhang, Kazunori Kawamura, Hiroshi Ito, Hidehiko Takahashi, Tetsuya Suhara, Makiko Yamada
Scientific Reports May 17, 2018 DOI: 10.1038/s41598-018-26382-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational neuroimaging study combining fMRI and PET Peer reviewed |
|---|---|
| Population | Healthy participants |
| Measures | visual analog scale, fMRI, [11C]raclopride PET |
| Citations | 5 |
| Key findings | Participants rated faded-looking objects as feeling more unreal than vivid ones despite identical physical saturation. Faded perception-related activity in the dorsolateral prefrontal and parietal cortex was positively correlated with striatal dopamine D2 receptor availability, which the authors propose may help explain the neuromolecular basis of unreality feelings in derealization. |
Abstract
Abstract Perceptual changes in shape, size, or color are observed in patients with derealization symptoms; however, the underlying neural and molecular mechanisms are not well understood. The current study explored the relationship between neural activity associated with altered colorfulness perception assessed by fMRI and striatal dopamine D2receptor availability measured by [11C]raclopride PET in healthy participants. Inside an fMRI scanner, participants performed the saturation adaptation task, where they rated how much vivid/faded visual objects looked like real/unreal ones using a visual analog scale. We found that participants experienced greater unreality when they perceived fadedness than vividness despite physically identical saturation. The combined fMRI and PET analyses revealed that the faded perception-related activities of the dorsolateral prefrontal and parietal cortex were positively correlated with striatal D2receptor availability. This finding may help to understand the neuromolecular mechanisms of faded perception associated with feeling unreal in derealization symptoms.
Citations in the library
Cited by 2
Cites 9
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