Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.
Christine A Rabinak, Chandra Sekhar Sripada, Mike Angstadt, Harriet de Wit, K Luan Phan
Journal of Neural Transmission June 2012 DOI: 10.1007/s00702-011-0747-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Double-blind crossover, placebo-controlled functional magnetic resonance imaging study Peer reviewed |
|---|---|
| Population | Humans |
| Key points | An acute oral dose of THC attenuated subgenual anterior cingulate cortex reactivity during the induction of negative affect, a result the authors say extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function. |
Abstract
Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆(9)-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.
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- Effect of Δ9-Tetrahydrocannabinol on Frontostriatal Resting State Functional Connectivity and Subjective Euphoric Response in Healthy Young Adults Drug and Alcohol Dependence February 3, 2021
- Altered orbitofrontal activity and dorsal striatal connectivity during emotion processing in dependent marijuana users after 28 days of abstinence. Psychopharmacology March 2018
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Cites 6
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- Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol The International Journal of Neuropsychopharmacology September 24, 2009
- Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology November 18, 2009
- Altered affective response in marijuana smokers: an FMRI study. Drug and Alcohol Dependence November 1, 2009
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