Association of Cannabis Use during Adolescence, Prefrontal CB1 Receptor Signaling, and Schizophrenia.
Adriana Caballero, Kuei Y Tseng
Frontiers in Pharmacology 2012 DOI: 10.3389/fphar.2012.00101 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Cannabis |
| Keywords | Adolescence Cannabinoids Prefrontal cortex Schizophrenia |
| Key findings | Argues that cannabinoid receptor 1 (CB1R) signaling in the prefrontal cortex is developmentally regulated and contributes to the acquisition of mature executive function, and hypothesizes that alterations in this signaling during adolescent maturation may confer liability to psychiatric disorders. |
Abstract
The cannabinoid receptor 1 (CB1R) is the G-protein coupled receptor responsible for the majority of the endocannabinoid signaling in the human brain. It is widely distributed in the limbic system, basal ganglia, and cerebellum, which are areas responsible for cognition, memory, and motor control. Because of this widespread distribution, it is not surprising that drugs that activate CB1R have expected behavioral outcomes consistent with dysregulated signaling from these areas (e.g., memory loss, cognitive deficits, etc). In the context of this review, we present evidence for the role of CB1R signaling in the prefrontal cortex (PFC), an area involved in executive functions, with emphasis on the developmental regulation of CB1R signaling in the acquisition of mature PFC function. We further hypothesize how alterations in CB1R signaling specifically during adolescent maturation might confer liability to psychiatric disorders.
Comparable studies
Other narrative reviews on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Causal association between cannabis and psychosis: examination of the evidence | 2004 | Review | |
| Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. General (historical and pharmacological review) | 2018 | Review | |
| Psychiatric effects of cannabis | 2001 | Review | |
| Beyond THC: The New Generation of Cannabinoid Designer Drugs | 2011 | Review | |
| Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug | 2006 | Review |
Citations in the library
Cited by 8
- Associations Between Cannabis, Psychosis, and Schizophrenia in Adolescents Academic Leadership Journal in Student Research 2022
- Adolescent cannabinoid exposure delays development of prefrontal cortex perineuronal nets and inhibitory interneurons. Neuroscience March 23, 2026
- Real world clinical outcomes of treatment of cannabis-induced psychosis and prevalence of cannabis-related primary psychosis: a retrospective study BMC Psychiatry September 27, 2024
- Adolescent exposure to delta-9-tetrahydrocannabinol and ethanol heightens sensitivity to fear stimuli. Behavioural Brain Research October 11, 2021
- Resting state functional connectivity in the default mode network: Relationships between cannabis use, gender, and cognition in adolescents and young adults NeuroImage: Clinical April 8, 2021
and 3 more in the library
Cites 7
- Causal association between cannabis and psychosis: examination of the evidence The British Journal of Psychiatry January 30, 2004
- Cannabis use before age 15 and subsequent executive functioning The British Journal of Psychiatry May 31, 2011
- Dose-related modulation of event-related potentials to novel and target stimuli by intravenous Δ⁹-THC in humans. Neuropsychopharmacology June 2012
- Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation. Journal of Neuroscience October 26, 2011
- Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. Biological Psychiatry March 15, 2005
and 2 more in the library