New medications for treatment-resistant depression: a brief review of recent developments.
CNS Spectrums December 2017 DOI: 10.1017/s1092852917000876 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Topics | Depression Esketamine Ketamine |
| Keywords | Alks-5461 Investigational antidepressants Rapastinel Therapies |
Abstract
There is a great unmet need for new medications with novel mechanisms of action that can effectively treat patients who do not benefit from standard antidepressant therapies. After a period in which it seemed as if the pharmaceutical pipeline for new antidepressants was going dry, the past decade has witnessed renewed interest, beginning with discovery of the antidepressant effects of ketamine. This article briefly highlights more recent research on ketamine and other investigational antidepressants.
Citations in the library
Cited by 4
- Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation American Journal of Psychiatry March 17, 2021
- An Update on Glutamatergic System in Suicidal Depression and on the Role of Esketamine Current Topics in Medicinal Chemistry January 31, 2020
- Have Effective Antidepressants Finally Arrived? Developments in Major Depressive Disorder Therapy. The Journal of Clinical Psychiatry August 14, 2023
- Ketamine for Treatment-Resistant Depression: A Gateway to Novel Treatment Approaches Journal of Psychosocial Nursing and Mental Health Services October 1, 2018
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and 10 more in the library