Overcoming Depression by Inhibition of Neural Burst Firing.
Daesoo Kim, Eunji Cheong, Hee-Sup Shin
Neuron June 6, 2018 DOI: 10.1016/j.neuron.2018.05.032 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Intervention | Ketamine |
| Topics | Depression |
| Key points | The text reports that two studies from Hailan Hu's laboratory indicate ketamine blocks burst firing of lateral habenula neurons, which rapidly relieves depression symptoms, offering a mechanism for ketamine's rapid and long-lasting antidepressant effects. |
Abstract
The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.