Efficacy of different doses of ketamine as a bolus in major depressive disorder.
Farzan Kheirkhah, Gooya Tayyebi, Seyed Mozaffar Rabiee, Ali-Akbar Moghadamnia, Ali Bijani
Caspian journal of internal medicine 2018 DOI: 10.22088/cjim.9.3.220 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Double-blind clinical controlled trial Peer reviewed |
|---|---|
| Sample size | 100 |
| Population | Patients with a primary diagnosis of major depressive disorder |
| Intervention | Ketamine |
| Dose | 0.5 mg/kg or 0.75 mg/kg |
| Duration | Assessments at 2, 7, 30, and 60 days after a single ketamine dose |
| Measures | Hamilton Depression Rating Scale, Beck Depression Inventory |
| Topics | Depression Ketamine Esketamine |
| Keywords | Bolus Infusion |
| Key findings | The authors report that ketamine's antidepressant effect depended on dose and route: 0.75 mg/kg was more effective than 0.5 mg/kg, bolus injection of 0.5 mg/kg was more effective than infusion at that dose, and at 0.75 mg/kg no difference appeared between bolus and infusion. Treatment response was 64% by Hamilton scores and 60% by Beck scores. |
Abstract
Major depressive disorder is a severe, heterogeneous, common medical illness and a leading cause of disability throughout the world that poses a significant public health issue. Previous studies have shown rapid antidepressant effects following a single administration of ketamine. This study aimed to assess the impact of route of administration and dose of ketamine for the reduction of depressive symptoms and compare the effects of different doses and methods. A double-blind clinical controlled trial was done on 100 patients with a primary diagnosis of major depressive disorder who were assigned into two groups of 50 subjects at a dose of 0.5 mg/kg and 0.75 mg/kg ketamine and each group was divided into two groups of 25 subjects following a single dose of intravenous bolus and infusion of ketamine. The patient's severity of depression was evaluated with Hamillton Depression Rating Scale and Beck Depression Inventory scores after 2 days, 7 days, 30 days and 60 days of ketamine administration, then the results were compared between groups. According to Hamilton and Beck score, the treatment response in investigated patients was 64% and 60%, respectively. These data suggest that ketamine effect is related to drug dose and type of administration. The dose of 0.75 mg/kg of ketamine is more effective than 0.5 mg/kg and a bolus injection of low-dose ketamine (0.5 mg/kg) is more effective than infusion and in high-dose ketamine (0.75 mg/kg), there was no difference between the methods of drug administration.
Comparable studies
Other randomized controlled trials on ketamine for depression, most cited first.
Citations in the library
Cites 15
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- Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial American Journal of Psychiatry August 28, 2013
- Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings) CNS Neuroscience & Therapeutics April 10, 2013
and 10 more in the library