Differential behavioral effects of ketamine between adolescent and adult Sprague-Dawley rats
Maria A. Greenwood
VCU Scholars Compass 2013 DOI: 10.25772/xrxb-ft46 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational animal study Peer reviewed |
|---|---|
| Population | Adolescent (PND 28-50) and adult (>PND70) Sprague-Dawley rats |
| Interventions | Ketamine Cocaine |
| Topics | Esketamine Ketamine |
| Citations | 1 |
| Key findings | Adolescent rats showed a conditioned place preference for ketamine while adults showed an aversion; adults acquired intravenous self-administration more rapidly, but there was no age difference in the percentage reaching acquisition or in progressive ratio responding for either drug. The authors suggest adolescents have greater sensitivity to ketamine's rewarding effects and tolerance to its aversive effects, and that cocaine produced only hedonic effects in both age groups. |
Abstract
The dissociative anesthetic ketamine has been subject to growing abuse worldwide, particularly in adolescents. This project compared the effects of ketamine in conditioned place preference and intravenous self-administration in adolescent (PND 28-50) and adult (>PND70) Sprague-Dawley rats. Cocaine served as a positive control. In CPP, adolescents demonstrated preferences for ketamine, while adults developed an aversion. In the self-administration procedure, adults acquired the behavior more rapidly, but there was no difference in the percentage of subjects reaching acquisition nor in responding under a progressive ratio schedule for either drug. The CPP results suggest that adolescents have a greater sensitivity to the rewarding and tolerance to the aversive effects of ketamine. The divergent results for ketamine in the adults may reflect differences in the two procedures. However, because cocaine produced only hedonic effects in both age groups, it also suggests unique characteristics of ketamine and differences in its effects based on age.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cites 9
- A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Archives of General Psychiatry August 1, 2006
- Taming the Ketamine Tiger Anesthesiology August 6, 2010
- Ketamine for chronic pain: risks and benefits British Journal of Clinical Pharmacology February 21, 2013
- Intravenous ketamine therapy in a patient with a treatment-resistant major depression Swiss Medical Weekly April 21, 2007
- The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use. Emerging health threats journal April 15, 2011
and 4 more in the library