Antidepressant Effect of Combined Ketamine and Electroconvulsive Therapy on Patients With Major Depressive Disorder: A Randomized Trial
Narges Shams-Alizadeh, Azad Maroufi, Karim Nasseri, Seyed Hosein Sadeghi Najafabadi, Ali Mousavi Taghiabad, Fardin Gharibi, Gholam-Reza Esfandiari
Iranian Journal of Psychiatry and Behavioral Sciences September 23, 2015 DOI: 10.17795/ijpbs-1578 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Double-blind randomized clinical trial Peer reviewed |
|---|---|
| Sample size | 42 |
| Population | Patients with major depressive disorder undergoing electroconvulsive therapy |
| Interventions | Ketamine Propofol |
| Duration | 2-week follow-up |
| Measures | Hamilton rating scale for depression |
| Topics | Depression Esketamine Ketamine |
| Citations | 34 |
| Key findings | Ketamine added to propofol anesthesia did not significantly improve depression recovery over a two-week follow-up compared with propofol alone, but was associated with faster cognitive performance recovery after ECT. |
Abstract
Background: One of the shortcomings of the available treatments for major depressive disorder (MDD) is the time delay between starting the treatment and achieving an antidepressant response.
Objectives: We aimed to determine the effect of Ketamine as a synergistic antidepressant and anesthetic agent on MDD in electroconvulsive therapy (ECT). PATIENTS AND
Methods: Twenty-two patients with MDD received Ketamine and Propofol as anesthetic agents compared with 20 patients as the control group who received Propofol in a double-blind randomized clinical trial. The Hamilton rating scale for depression was used to determine the changes in symptoms severity during ECT and a 2-week follow-up.
Results: Both groups showed a reduction in depression severity, but there was no significant difference between the groups in the recovery process (P = 0.92). However, the cognitive performance recovery time in the Ketamine group was lower than that in the control group (P = 0.042).
Conclusions: This study could not show the effect of Ketamine on depression recovery in a 2-week follow-up period. Nevertheless, Ketamine may provide a better cognitive performance in patients under ECT.
Comparable studies
Other randomized controlled trials on ketamine for depression, most cited first.
Citations in the library
Cited by 17
- Ketamine and depression: a narrative review Drug Design, Development and Therapy August 1, 2019
- Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review BJPsych Open December 23, 2021
- Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial The Lancet Psychiatry May 1, 2017
- Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder. Cochrane Database of Systematic Reviews September 12, 2021
- EFFICACY AND SAFETY OF RACEMIC KETAMINE AND ESKETAMINE FOR DEPRESSION: A SYSTEMATIC REVIEW AND META-ANALYSIS Expert Opinion on Drug Safety March 9, 2022
and 12 more in the library
Cites 9
- A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Archives of General Psychiatry August 1, 2006
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Science August 19, 2010
- Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Journal of Neuroscience April 15, 1997
- Intravenous ketamine therapy in a patient with a treatment-resistant major depression Swiss Medical Weekly April 21, 2007
- Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study. European Archives of Psychiatry and Clinical Neuroscience December 2011
and 4 more in the library