Paliperidone for the treatment of ketamine-induced psychosis: a case report.
M L Zuccoli, A Muscella, C Fucile, R Carrozzino, F Mattioli, A Martelli, S Orengo
The International Journal of Psychiatry in Medicine 2014 DOI: 10.2190/pm.48.2.c (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A poly-drug abuser with chronic oral ketamine consumption |
| Intervention | Paliperidone |
| Duration | Symptoms persisted more than two weeks after ketamine consumption stopped |
| Topics | Ketamine Esketamine |
| Keywords | Drug abuse Paliperidone Psychosis |
| Key findings | Chronic oral ketamine use in a poly-drug abuser induced agitation, behavioral abnormalities, and loss of contact with reality that persisted more than two weeks after ketamine cessation. Paliperidone treatment led to complete resolution of the psychosis. The authors contend paliperidone is very effective for ketamine-induced disorders and may suit smokers and alcohol abusers because its metabolism depends little on liver enzymes. |
Abstract
Ketamine is an anaesthetic and analgesic drug synthesized in the 1960s from phencyclidine. The recreational use of ketamine increased among the dance culture of techno and house music, in particular in clubs, discotheques, and rave parties. The psychotropic effects of ketamine are now well known and they range from dissociation to positive, negative, and cognitive schizophrenia-like symptoms. We report a case of a chronic oral consumption of ketamine which induced agitation, behavioral abnormalities, and loss of contact with reality in a poly-drug abuser; these symptoms persisted more than two weeks after the drug consumption had stopped. Antipsychotic treatment with paliperidone led to a successful management of the psychosis, getting a complete resolution of the clinical picture. Paliperidone has proven to be very effective in the treatment of ketamine-induced disorders. Moreover, the pharmacological action and metabolism of paliperidone are poorly dependent from the activity of liver enzymes, so that it seems to be one of the best second generation antipsychotics for the treatment of smokers and alcohol abusers.
Comparable studies
Other case reports and case series on ketamine, most cited first.
Citations in the library
Cites 5
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- Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions. International review of neurobiology 2007
- Club drugs: reasons for and consequences of use. Journal of Psychoactive Drugs September 2004
- Illicit use of ketamine in Scotland. Journal of Psychoactive Drugs 1996