Suicide prevention and ketamine: insights from computational modeling
Colleen E. Charlton, Povilas Karvelis, Roger S McIntyre, Andreea O. Diaconescu, Andreea O. Diaconescu, Andreea O. Diaconescu, Andreea O. Diaconescu
Frontiers in Psychiatry June 30, 2023 DOI: 10.3389/fpsyt.2023.1214018 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Ketamine Esketamine |
| Keywords | Computational modeling Generative models Innovative approach Powerful tool Simulate brain processes Ketamine treatment: ketamine Rapidly alleviates suicidality Influences neural circuits Personalized treatment strategies Suicidality: suicidality Alleviate suicidality Learning and decision-making Altered brain connectivity Receptor densities Precise mechanisms |
| Citations | 7 |
| Key findings | Computational modeling offers a promising approach to understand ketamine's anti-suicidal effects and identify personalized treatment strategies. |
Abstract
Suicide is a pressing public health issue, with over 700,000 individuals dying each year. Ketamine has emerged as a promising treatment for suicidal thoughts and behaviors (STBs), yet the complex mechanisms underlying ketamine’s anti-suicidal effect are not fully understood. Computational psychiatry provides a promising framework for exploring the dynamic interactions underlying suicidality and ketamine’s therapeutic action, offering insight into potential biomarkers, treatment targets, and the underlying mechanisms of both. This paper provides an overview of current computational theories of suicidality and ketamine’s mechanism of action, and discusses various computational modeling approaches that attempt to explain ketamine’s anti-suicidal effect. More specifically, the therapeutic potential of ketamine is explored in the context of the mismatch negativity and the predictive coding framework, by considering neurocircuits involved in learning and decision-making, and investigating altered connectivity strengths and receptor densities targeted by ketamine. Theory-driven computational models offer a promising approach to integrate existing knowledge of suicidality and ketamine, and for the extraction of model-derived mechanistic parameters that can be used to identify patient subgroups and personalized treatment approaches. Future computational studies on ketamine’s mechanism of action should optimize task design and modeling approaches to ensure parameter reliability, and external factors such as set and setting, as well as psychedelic-assisted therapy should be evaluated for their additional therapeutic value.
Comparable studies
Other narrative reviews on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms | 2018 | Review | |
| Mechanisms of Ketamine Action as an Antidepressant | 2018 | Review | |
| Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation Adults with treatment-resistant depression | 2021 | Review | |
| Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings) | 2013 | Review | |
| A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders | 2017 | Review and consensus statement |
Citations in the library
Cited by 3
- The Algorithmic Agent Perspective and Computational Neuropsychiatry: From Etiology to Advanced Therapy in Major Depressive Disorder Entropy November 6, 2024
- The association between ketamine and esketamine and suicidality: reports to the Food And Drug Administration Adverse Event Reporting System (FAERS). Expert Opinion on Drug Safety June 21, 2024
- From psychache to neuroplasticity: A unified rescue-repair model of Ketamine's anti-suicidal action. Neuroscience & Biobehavioral Reviews June 7, 2026
Cites 52
- A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Archives of General Psychiatry August 1, 2006
- Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms Pharmacological Reviews June 26, 2018
- REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics Pharmacological Reviews June 20, 2019
- Mechanisms of Ketamine Action as an Antidepressant Molecular Psychiatry March 13, 2018
- The Predictive Coding Account of Psychosis. Biological Psychiatry May 25, 2018
and 47 more in the library