Default Mode Network Dynamics in Covert Consciousness

Abstract

Compared Notably, DMN properties were completely absent in Patient 4 (P4), who had a behavioral diagnosis of VS but demonstrated covert consciousness on a functional magnetic resonance imaging (fMRI) motor imagery task. A yellow outline of the brain indicates an intact DMN property, defined by a Z-value (for correlations and anticorrelations) and percent of suprathreshold voxels (for deactivations) that is within the normal 2.5 th -to-97.5 th percentile of the healthy control group median. For example, P5 demonstrated intact DMN correlations while P6 demonstrated intact DMN correlations, anticorrelations, and deactivations. Color bars for correlations and anticorrelations represent Fisher-transformed Z values. The deactivation color bar represents the Z value for voxels surpassing a Z>3.1 and P=0.05 cluster-corrected threshold. All diagnoses are based on behavioral assessment with the Coma Recovery Scale-Revised, with the exception of the CMD diagnoses, which are based upon evidence of covert consciousness as described in Edlow et al., 2017 and Supplementary Materials.