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Characteristics
Observational study
Intervention
Ketamine
Topics
Anxiety
Depression
Esketamine
Ketamine
Keywords
Mental health treatment
Ketamine therapy
Depression & anxiety
Treatment efficacy
Safety profile
Key findings
Repeated at-home ketamine treatments are effective for depression, generalized anxiety, and social anxiety with a favorable safety profile.
Abstract
Objective To evaluate the effectiveness of repeated at-home ketamine treatments for depression, generalized anxiety, and social anxiety and assess safety in terms of adverse effects and tendency towards long-term use.
Comparable studies
Other observational and cohort studies on
ketamine for anxiety , most cited first.
Study
Year
Design
Participants
Treating bipolar depression with esketamine: Safety and effectiveness data from a naturalistic multicentric study on esketamine in bipolar versus unipolar treatment‐resistant depression
Patients with treatment-resistant bipolar depression (B-TRD) and unipolar...
2023
Observational cohort
n = 70
The effectiveness of ketamine on anxiety, irritability, and agitation: Implications for treating mixed features in adults with major depressive or bipolar disorder
Adults with treatment-resistant major depressive disorder or bipolar disorder
2020
Retrospective analysis
n = 201
At-home, sublingual ketamine telehealth is a safe and effective treatment for moderate to severe anxiety and depression: Findings from a large, prospective, open-label effectiveness trial.
Outpatients receiving at-home ketamine-assisted therapy
2022
Prospective study
n = 1,247
Predicting outcome with Intranasal Esketamine treatment: A machine-learning, three-month study in Treatment-Resistant Depression (ESK-LEARNING)
Treatment-resistant depression patients
2023
Retrospective, multicentric, real-world study
n = 149
Esketamine in treatment-resistant depression patients comorbid with substance-use disorder: A viewpoint on its safety and effectiveness in a subsample of patients from the REAL-ESK study
Patients with treatment-resistant depression and a substance use disorder
2023
Observational, retrospective, multicentre study
n = 26
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Related reading
Safety, effectiveness and tolerability of sublingual ketamine in depression and anxiety: A retrospective study of off-label, at-home use
Frontiers in Psychiatry
September 28, 2022
25 citations
Sublingual Ketamine for Treatment Resistant Depression: Embracing the Change
BJPsych Open
June 1, 2025
At-Home Telehealth-Supported Subcutaneous Ketamine Therapy in Adults With Moderate to Severe Depression, Anxiety, or PTSD: A Real-World Observational Study of Safety, Feasibility, and Clinical Outcomes in a Large, Heterogeneous Cohort in the United States.
Journal of Medical Internet Research
June 17, 2026
At-Home Telehealth-Supported Subcutaneous Ketamine Therapy for Depression, Anxiety, and PTSD: A Real-World Observational Study of Safety, Feasibility, and Effectiveness in a Large Cohort (Preprint)
Real-world depression, anxiety and safety outcomes of intramuscular ketamine treatment: a retrospective descriptive cohort study
BMC Psychiatry
October 3, 2022
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