Use of Ketamine Infusions for Treatment of Complex Regional Pain Syndrome: A Systematic Review
Anand S. Patil, Ahish Chitneni, Suhani Dalal, Joe Ghorayeb, Yolanda Pham, Gregory Grigoropoulos
medRxiv Preprint Server April 20, 2021 preprint DOI: 10.1101/2021.04.20.21255840 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review |
|---|---|
| Population | Patients with treatment-resistant Complex Regional Pain Syndrome (CRPS) |
| Intervention | ketamine infusion |
| Topics | Esketamine Ketamine |
| Keywords | Crps Chronic pain syndrome Ketamine therapy Ketamine infusions Pain treatment Medical treatment Pain management Chronic pain relief Pain alleviation Severe chronic pain Persistent pain |
| Key findings | Ketamine infusions may reduce pain for some patients with treatment-resistant CRPS, but the evidence is limited and of low quality. |
Abstract
Background This systematic review aims to review clinical studies on the use of ketamine infusion for patients with treatment-resistant Complex Regional Pain Syndrome (CRPS).
Comparable studies
Other systematic reviews and meta-analyses on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis Depressed patients with suicidal ideation at baseline | 2017 | Systematic review and individual participant data meta-analysis | n = 167 |
| Ketamine use: a review Ketamine users | 2011 | Systematic review | |
| Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression Participants with major depression in placebo-controlled, double-blind, randomized... | 2015 | Systematic review and meta-analysis | |
| Ketamine and postoperative pain – a quantitative systematic review of randomised trials Surgical patients from 25 countries | 2004 | Systematic review | n = 2,839 |
| Side-effects associated with ketamine use in depression: a systematic review. Patients with depression | 2018 | Systematic review |
Citations in the library
Cites 5
- Ketamine use: a review Addiction July 21, 2011
- Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study Biological Psychiatry November 4, 2015
- Ketamine – More mechanisms of action than just NMDA blockade Trends in Anaesthesia and Critical Care March 22, 2014
- KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS Depression and Anxiety April 6, 2016
- Psychological effects of ketamine in healthy volunteers. Phenomenological study. The British Journal of Psychiatry August 1, 2006