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NOVEL MANAGEMENT OF DEPRESSION USING KETAMINE IN THE INTENSIVE CARE UNIT

Nirmaljot Kaur, Siva Naga S. Yarrarapu, Abhishek R. Giri, Kathleen A. Rottman Pietrzak, Christan Santos, Philip E. Lowman, Shehzad Niaz, Pablo Moreno Franco, Devang K. Sanghavi

medRxiv Preprint Server September 23, 2021 preprint DOI: 10.1101/2021.09.23.21262316 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Case study Case report
Intervention Ketamine
Topics Depression Esketamine Ketamine
Keywords Ketamine depression treatment Intensive care psychiatry Rapid antidepressant effect Novel therapies
Key findings Ketamine can be effectively used for depression management in the intensive care unit.

Abstract

Background Ketamine, a dissociative anesthetic, induces remission of depression by antagonizing glutaminergic NMDA receptors. Ketamine has been used previously in outpatient setting for treatment-resistant depression, but we showcase its utility in depression management at the Intensive Care Unit (ICU).

Comparable studies

Other case reports and case series on ketamine for depression, most cited first.

Study Year Design Participants
Electroconvulsive Therapy, Ketamine, and Esketamine in a Patient with Major Depressive Disorder and Multiple Comorbidities: A Case Report over 10-year Treatment from Adolescence to Adulthood. A patient with treatment-resistant depression and comorbid generalized anxiety... 2025 Case report n = 1
A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment‐resistant depression Patients with enduring eating disorders and treatment-resistant depression 2021 Case series n = 4
Effects of intranasal (S)-ketamine on Veterans with co-morbid treatment-resistant depression and PTSD: A retrospective case series Veterans with co-morbid depression and PTSD 2022 Retrospective case series n = 35
Case report: Intramuscular ketamine or intranasal esketamine as a treatment in four patients with major depressive disorder and comorbid anorexia nervosa Patients with anorexia nervosa and a comorbid depressive disorder treated at a private... 2023 Case report n = 4
Repeated oral esketamine in patients with treatment resistant depression and comorbid posttraumatic stress disorder Patients with treatment-resistant depression and comorbid PTSD 2023 Case series n = 5

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Depression Esketamine Ketamine

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Ketamine for depression