NOVEL MANAGEMENT OF DEPRESSION USING KETAMINE IN THE INTENSIVE CARE UNIT
Nirmaljot Kaur, Siva Naga S. Yarrarapu, Abhishek R. Giri, Kathleen A. Rottman Pietrzak, Christan Santos, Philip E. Lowman, Shehzad Niaz, Pablo Moreno Franco, Devang K. Sanghavi
medRxiv Preprint Server September 23, 2021 preprint DOI: 10.1101/2021.09.23.21262316 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report |
|---|---|
| Intervention | Ketamine |
| Topics | Depression Esketamine Ketamine |
| Keywords | Ketamine depression treatment Intensive care psychiatry Rapid antidepressant effect Novel therapies |
| Key findings | Ketamine can be effectively used for depression management in the intensive care unit. |
Abstract
Background Ketamine, a dissociative anesthetic, induces remission of depression by antagonizing glutaminergic NMDA receptors. Ketamine has been used previously in outpatient setting for treatment-resistant depression, but we showcase its utility in depression management at the Intensive Care Unit (ICU).