Serotonin syndrome with dextromethorphan alone and in combination with other serotonergic drugs. a systematic review.
Jianhao Deng, Jiaxing Zhang, QingXia Zhang, Guowei Zhong
May 12, 2022 DOI: 10.37766/inplasy2022.5.0079 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review protocol |
|---|---|
| Intervention | Dextromethorphan |
| Topics | Serotonin |
| Key findings | Proposes a systematic review to assess evidence on whether dextromethorphan, alone or in therapeutic doses, can cause serotonin syndrome, and whether concurrent serotonergic medication is associated with its occurrence, noting that this question remains uncertain and has not been systematically reviewed before. |
Abstract
Review question / Objective: To assess the evidence for serotonin syndrome occurring in the context of dextromethorphan administration. To assess concurrent medication to see if there are associations with 1) other serotonergic medication. Condition being studied: It is uncertain whether use of dextromethorphan alone or in therapeutic doses can cause Serotonin syndrome (SS). Also, SS by dextromethorphan has not previously been systematically reviewed. Therefore, the main aim is to present a systematic review and summary of these studies.
Comparable studies
Other systematic reviews and meta-analyses on serotonin, most cited first.