Ketamine, Clio, and the hippocratic triangle—fragments of the history of ketamine
C. Cabrera-Abreu, Mariel Cabrera-Mendez
2021 DOI: 10.1016/b978-0-12-821033-8.00001-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Historical analysis |
|---|---|
| Topics | Esketamine Ketamine |
| Key points | Argues that the history of ketamine, particularly its relationship to the concept of "dissociation" and Edward Domino's encounters with its psychotropic effects, illustrates psychiatry's constant reinvention and shifting paradigms rather than yielding definitive conclusions about the future of psychopharmacology or glutamate antagonists. |
Abstract
abstract The objective of this chapter is to highlight some intriguing aspects of the history of ketamine. First, we will review the methodologies used when writing a small fragment of the overall history of psychopharmacology. Second, and due to the recent explosion of papers on ketamine and related substances in the past decade, we have focused on two themes, the interplay of ketamine with the nosologic status of “dissociation” and the repeated encounters of Edward Domino with ketamine and some of its psychotropic effects. Finally, this chapter does not end offering some inchoate conclusions or pretentious sagely advice about the future of psychopharmacology and the glutamate antagonists but rather wishes to be a critical reflection on psychiatry's constant reinvention and shifting paradigms, as it has been fashionable to say since Kuhn.
Comparable studies
Other theoretical and historical papers on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs. | 2014 | Historical analysis | |
| A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics | 2020 | Theoretical or philosophical paper | |
| Neuroscience and the Near-Death Experience: Roles for the NMSA-PCP receptor, the sigma receptor and the endopsychosins | 1990 | Theoretical or philosophical paper | |
| A unified model of ketamine's dissociative and psychedelic properties. | 2022 | Theoretical or philosophical paper | |
| An Integrative Approach to Ketamine Therapy May Enhance Multiple Dimensions of Efficacy: Improving Therapeutic Outcomes With Treatment Resistant Depression. | 2021 | Theoretical or philosophical paper |
Citations in the library
Cites 13
- Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans Archives of General Psychiatry March 1, 1994
- Recent advances in the phencyclidine model of schizophrenia American Journal of Psychiatry October 1, 1991
- Study of a New Schizophrenomimetic Drug—Sernyl Archives of Neurology And Psychiatry March 1, 1959
- Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS) Journal of Traumatic Stress 1998
- Taming the Ketamine Tiger Anesthesiology August 6, 2010
and 8 more in the library