Natural Product Mushroom Alkaloid Muscimol
The Chemical Educator February 1, 2023 DOI: 10.1333/s00897232979a (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Key findings | The review catalogs the numerous synthetic approaches designed to synthesize muscimol, an isoxazole alkaloid from Amanita muscaria, and provides guidance for preparing valuable muscimol analogues, motivated by muscimol's affinity for the GABAA receptor and its biological activity. |
Abstract
Muscimol is an isoxazole alkaloid isolated from the iconic mushroom Amanita muscaria. Although relatively small in size, muscimol has attracted great attention in the neurochemistry area based on its affinity for the GABAA receptor and its biological activity. The review relates the numerous synthetic approaches which have been designed to synthesize muscimol and also provided guidance to prepare valuable muscimol analogues.