ECT more efficacious than ketamine in reducing depression severity
The Brown University Psychopharmacology Update February 1, 2023 DOI: 10.1002/pu.30969 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review and meta-analysis Peer reviewed |
|---|---|
| Population | Patients with a major depressive episode |
| Interventions | Electroconvulsive therapy (ECT) ketamine |
| Topics | Depression Esketamine Ketamine |
| Key findings | Electroconvulsive therapy is more efficacious than ketamine in reducing depressive symptom severity in patients with a major depressive episode, with no significant between-group differences in adverse event prevalence. |
Abstract
Results of a systematic review and meta‐analysis comprising six clinical trials suggest that electroconvulsive therapy (ECT) is more efficacious than ketamine in reducing the severity of depressive symptoms in patients with a major depressive episode. No significant between‐group differences in the prevalence of adverse events were observed. Results of the meta‐analysis were published online Oct. 19, 2022 in JAMA Psychiatry.
Comparable studies
Other systematic reviews and meta-analyses on ketamine for depression, most cited first.