The use of cannabinoid therapy in treatment-refractory isolated REM sleep behavior disorder: a case report
Sahej Samra, Hrayr Attarian, R. Malkani
Journal of Clinical Sleep Medicine March 25, 2025 DOI: 10.5664/jcsm.11704 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A patient with treatment-refractory isolated REM sleep behavior disorder |
| Interventions | Cannabidiol Tetrahydrocannabinol |
| Duration | 5 years of follow-up |
| Key findings | The authors report that a patient with treatment-refractory isolated REM sleep behavior disorder had a dramatic and sustained improvement in dream enactment behaviors while using oral cannabidiol and tetrahydrocannabinol tinctures, with no adverse events over 5 years of follow-up. They present this as a potential treatment option warranting further study. |
Abstract
Current treatments for rapid eye movement sleep behavior disorder are not always effective and can lead to dose-limited adverse events, and new treatments are needed for this condition. We present a case of a patient with treatment-refractory isolated rapid eye movement sleep behavior disorder who had a dramatic and sustained improvement in dream enactment behaviors using oral tinctures containing cannabidiol and tetrahydrocannabinol without adverse events over 5 years of follow-up. Samra S, Attarian H, Malkani R. The use of cannabinoid therapy in treatment-refractory isolated REM sleep behavior disorder: a case report. J Clin Sleep Med. 2025;21(7):1311–1313.