Suppression of Deactivation of Working Memory and Promotion of Activation of Sustained Attention in the Default Mode Network Are Affected by Schizotypy in a Large Sample of Nonclinical Subjects
Seishu Nakagawa, Hikaru Takeuchi, Y. Taki, Ryoichi Yokoyama, Kohei Sakaki, Kelssy Hitomi Dos Santos Kawata, Takayuki Nozawa, Susumu Yokota, T. Araki, R. Nouchi, Ryuta Kawashima
Brain and Behavior May 1, 2025 DOI: 10.1002/brb3.70449 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Nonclinical subjects |
| Topics | Default mode network |
| Key points | The authors propose to identify the neural correlates of schizotypy during sustained attention and working memory tasks in nonclinical subjects, based on prior evidence linking maladaptive schizotypy to default mode network disturbance and working memory impairment. No results are reported in the abstract. |
Abstract
Schizotypy is a personality trait characterized by subclinical expression of the signs and symptoms of schizophrenia. Maladaptive schizotypy is given the clinical designation of schizotypal personality disorder. Previous studies have shown that functional disturbance of the default mode network (DMN) is associated with maladaptive schizotypy. Working memory impairment is a particularly common feature of maladaptive schizotypy and schizophrenia. As these characteristics can also be observed in the healthy population, our purpose was to identify the neural correlates of schizotypy during sustained attention tasks and working memory tasks in nonclinical subjects.