Claustrum-dependent timing of cortical metastability: a neural basis for behavioral flexibility and a target for psychedelic therapy
OHSU Digital Commons 2026 DOI: 10.6083/bpxhc45577 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Topics | Psychedelic-assisted therapy |
| Key points | Proposes that behavioral flexibility depends on the moment-to-moment timing of frontal cortical state transitions controlled by a reciprocally coupled subcortical circuit, and that this timing mechanism can be pathologically disrupted or pharmacologically restored. |
Abstract
This dissertation presents three interlocking empirical studies united by a single dynamical systems framework: that behavioral flexibility depends on the moment-to-moment timing of frontal cortical state transitions by a reciprocally coupled subcortical circuit, and that this timing mechanism can be pathologically disrupted or pharmacologically restored.